The Institute of Metabolic and Cardiovascular Diseases (I2MC) is recognized for its translational
research in the field of metabolic (obesity, diabetes, dyslipidemias) and cardiovascular (thrombosis,
atherosclerosis, cardiac and renal failure) diseases. Currently, the I2MC is composed of 11 teams.
Translation to the clinic is greatly facilitated by the location within the Rangueil site of Toulouse
University Hospitals. Notably, clinical departments devoted to nutrition, cardiovascular and renal
diseases, obesity and diabetes are in close vicinity of I2MC.
I2MC offers scientists a diverse set of competence through its 7 core facilities (Lipidomics, Imaging,
Bioinformatics, Functional Biochemistry, Cytometry, Histology, Genomics & Transcriptomics).
The overarching goal of the research in the laboratory of Dr. Martinez (LiMitAging Team) is to
explore the relation between some actors of mitochondrial functions and aging, and is driven by the
hypothesis that enhancing mitochondrial health and mitochondrial quality-control mechanisms will
promote healthy aging. In particular, the team's research in the field of lipoprotein and mitochondria
led to identify original actors associated to lipid and mitochondrial energy metabolism.
https://pubmed.ncbi.nlm.nih.gov/?term=martinez+LO&sort=date
The project will aim to explore the regulation and function of a novel regulator of mitochondrial
oxidative phosphorylation (OXPHOS) at the cell, organ, and whole-organism levels and in different
pathophysiological conditions. Pharmacological approaches to target mitochondrial energy
metabolism will be also explored.
We are seeking talented, conscientious, motivated and enthusiastic postdoctoral scientists
interested in the field of mitochondrial biology to join our team. Dr. Martinez is committed to
provide the training and resources needed for the lab members to achieve their goals at any point in
their career path in an inclusive and inspirational environment.
Desired qualification:
• Molecular, biochemical and cellular imaging methods to study mitochondria
• Knowledge in mitochondrial energy metabolism
• Experience with any specific disease or organ dysfunction in mice (liver, muscle, adipose
tissue, vascular endothelium)
• RNA-Seq and OMICs data analyses
Eligibility criteria:
• PhD in biology
• All nationalities
Apply now to Laurent.martinez@inserm.fr with letter of motivation, CV and email of 2-3 references.
